Victor Manolov
Medical University in Sofia, Bulgaria
Title: Evaluation of iron homeostasis parametrs in patients with obstructive sleep apnea
Biography
Biography: Victor Manolov
Abstract
Obstructive sleep apnea syndrome (OSA) is defined as a combination of symptoms as a result of intermittent, recurrent constraint and / or complete airway overhead airway overflow (sleep disturbance). OSA is associated with the development of insulin resistance, arterial hypertension, metabolic syndrome, systemic atherosclerosis and increased cardiovascular risk. 49 patients with OSA were included; age 44.1 ± 7.7. Their results were compared to sex and age matched healthy control. CBC, serum iron, ferritin, hsCRP, hepcidin, homocysteine and vitamin B12 were measured in the included groups. IMT and FMT were used for atherosclerotic changes evaluation. We found increased serum hepcidin levels in OSA patients with IMT and FMD changes (129.9 ± 20.4 μg/L) compared to control group (20.9 ± 1.7 μg/L); P<0.001. A positive correlation was found in OSA patients with atherosclerotic changes between IMT and FMD to serum hepcidin levels (r=0.811, r=0.829, resp.; P<0.005). Serum hepcidin correlates positively to homocysteine and vitamin B12 in OSA patients (r=0.809, r=0.855, resp.; P<0.01). Brain-vascular disease risk factors are connected to obstructive sleep apnea syndrome. Disregulation of iron homeostasis is one of the main risk atherogenesis factors. Early hepcidin quantification might predict an atherosclerosis occurrence in OSA patients, which might be very important for better clinical diagnosis and practice.
Acknowledgements: This project is sponsored by MU-Sofia, as part of Grant Д-52/2018.